Department of Obstetrics and Gynecology, Pomeranian Medical University, Szczecin, Poland.
J Perinatol. 2010 Oct;30(10):655-9. doi: 10.1038/jp.2010.22. Epub 2010 Mar 4.
The aim of this study was to evaluate the usefulness of maternal serum and vaginal fluid C-reactive protein (CRP) determinations in the prediction of neonatal congenital infection.
Fifty women between 24 and 36 weeks gestation, complicated by preterm premature rupture of membranes (pPROM), were divided into two groups according to the presence (n=14) or absence (n=36) of early-onset newborns' infection.
Maternal serum and vaginal fluid CRP concentrations were comparable between both groups. Serum CRP levels ≥10 and ≥15 mg l(-1) predicted neonatal infection with a sensitivity of 47 and 47%, specificity of 63 and 76%, positive predictive value (PPV) of 38 and 47%, and negative predictive value (NPV) of 72 and 76%, respectively. The cutoff value of vaginal CRP ≥2.4 mg l(-1) predicted infection with a sensitivity of 71%, specificity of 47%, PPV of 34%, and NPV of 81%. Receiver-operating characteristic curve analysis revealed that the predictive performance of CRP was poor.
Maternal serum and vaginal fluid CRP determinations after pPROM are of poor predictive value in neonatal early-onset infection prediction.
本研究旨在评估母体血清和阴道液 C 反应蛋白（CRP）测定在预测新生儿先天性感染中的作用。
选择 24 至 36 周妊娠合并早产胎膜早破（pPROM）的 50 名孕妇，根据是否存在（n=14）或不存在（n=36）早发型新生儿感染将其分为两组。
两组母体血清和阴道液 CRP 浓度无差异。血清 CRP 水平≥10 和≥15 mg l(-1)预测新生儿感染的灵敏度为 47%和 47%，特异性为 63%和 76%，阳性预测值（PPV）为 38%和 47%，阴性预测值（NPV）为 72%和 76%。阴道 CRP≥2.4 mg l(-1)的临界值预测感染的灵敏度为 71%，特异性为 47%，PPV 为 34%，NPV 为 81%。受试者工作特征曲线分析表明 CRP 的预测性能较差。
pPROM 后母体血清和阴道液 CRP 测定对预测新生儿早发型感染的预测价值较低。
