抗癫痫药物在马来西亚公立医院儿科患者中的应用与癫痫发作结果。

Antiepileptic drug utilisation and seizure outcome among paediatric patients in a Malaysian public hospital.

机构信息

School of Pharmaceutical Sciences, Universiti Sains Malaysia, and Department of Paediatrics, Penang General Hospital, Penang 11800, Malaysia.

出版信息

Singapore Med J. 2010 Jan;51(1):21-7.

PMID:20200771

Abstract

INTRODUCTION

The primary purpose of this study was to evaluate the utilisation pattern and seizure outcome of newer and older antiepileptic drugs in paediatric clinical practice in a Malaysian hospital setting.

METHODS

Over a two-month period, all paediatric epilepsy patients from Penang General Hospital, Malaysia who were diagnosed according to the classification of the International League Against Epilepsy were followed up prospectively, and the patients' information was gathered with the help of a validated data collection form. This included demographic characteristics, monotherapy and polytherapy of antiepileptic drugs, as well as the number of seizures experienced.

RESULTS

Partial seizures, including complex and simple partial seizures (47.2 percent), followed by generalised seizures (40 percent), were the most common seizure types found in this study. An average of 1.51 antiepileptic drugs per patient was prescribed, with 54.3 percent of the patients on monotherapy and 45.7 percent on polytherapy. Overall, sodium valproate was the most frequently prescribed antiepileptic drug (36.8 percent), followed by carbamazepine (30.2 percent) and lamotrigine (10.4 percent). Carbamazepine was the most frequently prescribed monotherapy (28.6 percent), followed by sodium valproate (17.1 percent). The newer antiepileptic drugs were also found to be used as monotherapy in 7.2 percent of the cases. Moreover, a significant difference was observed between the older and newer antiepileptic drugs in terms of the number of seizures experienced (p=0.027). Most (75 percent) of the seizure-free patients were on carbamazepine monotherapy.

CONCLUSION

Monotherapy was the most frequently used remedy in all forms of epilepsy. Overall, sodium valproate was the most commonly used drug, while carbamazepine was found to be more frequently used as monotherapy. There was a significant difference found between the older and newer antiepileptic drugs, with 87.5 percent of seizure-free patients on older antiepileptic drugs.

摘要

简介

本研究的主要目的是评估在马来西亚一家医院的儿科临床实践中，新型和旧型抗癫痫药物的使用模式和癫痫发作结果。

方法

在两个月的时间里，对马来西亚槟城总医院根据国际抗癫痫联盟分类诊断为癫痫的所有儿科癫痫患者进行前瞻性随访，并在一份经过验证的数据收集表的帮助下收集患者的信息。这包括人口统计学特征、抗癫痫药物的单药和联合治疗以及癫痫发作次数。

结果

本研究中最常见的癫痫发作类型是部分性发作，包括复杂和简单部分性发作（47.2%），其次是全面性发作（40%）。每位患者平均开具 1.51 种抗癫痫药物，54.3%的患者接受单药治疗，45.7%的患者接受联合治疗。总体而言，丙戊酸钠是最常开的抗癫痫药物（36.8%），其次是卡马西平（30.2%）和拉莫三嗪（10.4%）。卡马西平是最常开的单药治疗药物（28.6%），其次是丙戊酸钠（17.1%）。新型抗癫痫药物也被发现作为单药治疗在 7.2%的病例中使用。此外，在癫痫发作次数方面，新旧抗癫痫药物之间存在显著差异（p=0.027）。大多数（75%）无癫痫发作的患者接受卡马西平单药治疗。