Egunsola Oluwaseun, Choonara Imti, Sammons Helen M
Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Derbyshire Children's Hospital, Derby, UK.
Department of Paediatrics, North Devon District Hospital, Raleigh Park, Barnstaple, Devon, UK.
BMJ Paediatr Open. 2017 Aug 11;1(1):e000088. doi: 10.1136/bmjpo-2017-000088. eCollection 2017.
This study aims to determine global anti-epileptic drug (AED) utilisation prevalence and describe utilisation trends in different countries.
Databases Embase (1980-May 2017), Medline (1946-May 2017) and PubMed were searched for original research on AED utilisation. All paediatric national or regional database studies and surveys were included.
Twenty-one studies were identified. Five were excluded from the analysis as the data were collected before 2005, leaving 16 studies. Monotherapy regimen varied between 58% and 94% in different countries. In several of the studies, sodium valproate was the most frequently prescribed AED. However, there is a trend towards increasing utilisation of new-generation AEDs, particularly levetiracetam, in some countries.
Monotherapy was used in 58%-94%of patients. There is increasing utilisation of the new-generation AEDs, in particular lamotrigine, levetiracetam and topiramate. Old-generation AEDs are still used in the majority of patients. There is a need for up-to-date studies to determine the prevalence of AEDs in children.
本研究旨在确定全球抗癫痫药物（AED）的使用患病率，并描述不同国家的使用趋势。
检索数据库Embase（1980年至2017年5月）、Medline（1946年至2017年5月）和PubMed，以获取关于AED使用的原始研究。纳入所有儿科国家或地区数据库研究及调查。
共识别出21项研究。5项研究因数据收集于2005年之前而被排除在分析之外，最终纳入16项研究。不同国家的单药治疗方案比例在58%至94%之间。在多项研究中，丙戊酸钠是最常处方的AED。然而，在一些国家，新一代AED的使用有增加趋势，尤其是左乙拉西坦。
58% - 94%的患者使用单药治疗。新一代AED的使用在增加，特别是拉莫三嗪、左乙拉西坦和托吡酯。大多数患者仍在使用老一代AED。需要开展最新研究以确定儿童中AED的患病率。
