INSERM, U848, Villejuif, France.
Eur J Immunol. 2010 Mar;40(3):627-30. doi: 10.1002/eji.200940160.
The term "pyroptosis" was originally introduced to describe a particular form of cell death in macrophages, which is induced by bacterial infection, is accompanied by caspase-1 activation and hence leads to the release of pyrogenic interleukins; however, it is still controversial whether pyroptosis - which can also be triggered by non-bacterial pathological stimuli - truly represents a cell death modality on its own or whether it constitutes a special case of apoptosis or necrosis.
“细胞焦亡”一词最初被用来描述巨噬细胞中一种特定形式的细胞死亡,这种死亡是由细菌感染诱导的,伴随着半胱天冬酶-1 的激活,从而导致发热细胞因子的释放;然而,细胞焦亡是否真正代表一种独立的细胞死亡方式,或者它是否构成细胞凋亡或细胞坏死的一种特殊情况,仍然存在争议;这种细胞焦亡也可以被非细菌性病理刺激所触发。