Vittorini Maria Grazia, Sahin Aysenur, Trojan Antonin, Yusifli Sevil, Alashvili Tamta, Bonifácio Gonçalo V, Paposhvili Ketevan, Tischler Viktoria, Lampl Christian, Sacco Simona
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Faculty of Medicine-Acibadem Mehmet, Ali Aydinlar University, Istanbul, Turkey.
J Headache Pain. 2024 Mar 11;25(1):34. doi: 10.1186/s10194-024-01741-2.
Glymphatic system is an emerging pathway of removing metabolic waste products and toxic solutes from the brain tissue. It is made of a network of perivascular spaces, filled in cerebrospinal and interstitial fluid, encompassing penetrating and pial vessels and communicating with the subarachnoid space. It is separated from vessels by the blood brain barrier and from brain tissue by the endfeet of the astrocytes rich in aquaporin 4, a membrane protein which controls the water flow along the perivascular space. Animal models and magnetic resonance (MR) studies allowed to characterize the glymphatic system function and determine how its impairment could lead to numerous neurological disorders (e.g. Alzheimer's disease, stroke, sleep disturbances, migraine, idiopathic normal pressure hydrocephalus). This review aims to summarize the role of the glymphatic system in the pathophysiology of migraine in order to provide new ways of approaching to this disease and to its therapy.
类淋巴系统是一条从脑组织中清除代谢废物和有毒溶质的新途径。它由血管周围间隙网络构成，充满脑脊液和间质液，环绕穿通血管和软脑膜血管，并与蛛网膜下腔相通。它通过血脑屏障与血管分隔，通过富含水通道蛋白4的星形胶质细胞终足与脑组织分隔，水通道蛋白4是一种控制沿血管周围间隙水流的膜蛋白。动物模型和磁共振（MR）研究使人们能够描述类淋巴系统的功能，并确定其功能受损如何导致多种神经系统疾病（如阿尔茨海默病、中风、睡眠障碍、偏头痛、特发性正常压力脑积水）。本综述旨在总结类淋巴系统在偏头痛病理生理学中的作用，以便为治疗该疾病提供新的方法。
