[In vitro susceptibility of staphylococci to ciprofloxacin].

OBJECTIVE

To evaluate the in vitro activity of ciprofloxacin against communitary and hospital staphylococcal strains isolated during 2006-2008 in Eastern region of Romania.

MATERIAL AND METHODS

We have tested 1022 staphylococci strains, identified by conventional laboratory methods. Minimum inhibitory concentrations (MICs) were determined by agar dilution method, according to NCCLS.

RESULTS

For both hospital and communitary isolates, MIC 90 was 0.25 mg/L (4 fold less than breakpoint for sensitivity). Resistance was absent or reduced (1.7%) for coagulase- positive staphylococci, both communitary and hospital. For coagulase negative staphylococci, resistance for clinical strains is increased (6%) compared to comunitary strains (0.3%). In conclusion, ciprofloxacin is highly effective against staphylococci representing a therapeutic option for multiresistant strains. Our data shown the necessity of adequate antibiotic use in the hospital and community.