Horenko Z A, Karbovs'ka L S, Mehdi S P H, Luk'ianenko I A, Vesel's'kyĭ S P
Fiziol Zh (1994). 2009;55(6):55-62.
We studied the effect of the synthetic analogue of antidiuretic hormone-desmopressin on the level of choleresis and the bile acids spectrum in acute experiments in bile duct-cannulated rats. It is shown that desmopressin increases bile flow and concentration of taurin-conjugated bile acids. In this situation, the concentration ofglycocholates practically is not changed, and concentration of free bile acids is diminished, which results in increase in the conjugation coefficient. Blockade of V(1a) vasopressin receptors decreases the efficiency of desmopressin regulatory effect on certain aspects of bile secretion. Indexes of choleresis volume velocity were less than those obtained following peptide introduction. The changes in concentration of conjugated and free bile acids had opposite dynamics. Concentration of tauro- and glycocholates was diminished, while concentration of free bile acids was increased, which resulted in a decrease in conjugation coefficient. The data obtained indicate that desmopressin affects both the synthesis and in a higher degree the conjugation process of bile acids with amino acids through V(1a) vasopressin receptors.
我们在胆管插管大鼠的急性实验中研究了抗利尿激素合成类似物——去氨加压素对胆汁分泌水平和胆汁酸谱的影响。结果表明，去氨加压素可增加胆汁流量以及牛磺酸结合型胆汁酸的浓度。在这种情况下，甘氨胆酸盐的浓度实际上没有变化，游离胆汁酸的浓度降低，这导致结合系数增加。V(1a)血管加压素受体的阻断降低了去氨加压素对胆汁分泌某些方面的调节作用效率。胆汁分泌体积速度指标低于注射该肽后获得的指标。结合型和游离胆汁酸浓度的变化呈现相反的动态。牛磺胆酸盐和甘氨胆酸盐的浓度降低，而游离胆汁酸的浓度增加，这导致结合系数下降。所获得的数据表明，去氨加压素通过V(1a)血管加压素受体影响胆汁酸与氨基酸的合成，且在更大程度上影响其结合过程。
