Hantson P, Di Fazio V, Wallemacq P
Department of Intensive Care, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium.
Drug Metab Lett. 2010 Jan;4(1):7-8. doi: 10.2174/187231210790980426.
A 47-year-old woman ingested an overdose of 8000 mg quetiapine. The treatment had been initiated 3 weeks before. The current medications were lamuvidine, ritonavir, atazanavir and tenofovir for an HIV infection. The patient presented a deep coma and sustained hypotension as main complications. The toxicokinetic data revealed a markedly prolonged elimination half-life for quetiapine (62.4 hours) and the relationship with antiretroviral therapy is discussed.
一名47岁女性过量服用了8000毫克喹硫平。治疗于3周前开始。目前的药物包括拉米夫定、利托那韦、阿扎那韦和替诺福韦，用于治疗HIV感染。该患者出现深度昏迷和持续性低血压作为主要并发症。毒代动力学数据显示喹硫平的消除半衰期明显延长（62.4小时），并讨论了其与抗逆转录病毒治疗的关系。
