钠碘转运体的生物学特性及其在靶向基因传递中的应用。
The biology of the sodium iodide symporter and its potential for targeted gene delivery.
机构信息
The Institute of Cancer Research, 237 Fulham Road, London SW36JB, UK.
出版信息
Curr Cancer Drug Targets. 2010 Mar;10(2):242-67. doi: 10.2174/156800910791054194.
Abstract
The sodium iodide symporter (NIS) is responsible for thyroidal, salivary, gastric, intestinal and mammary iodide uptake. It was first cloned from the rat in 1996 and shortly thereafter from human and mouse tissue. In the intervening years, we have learned a great deal about the biology of NIS. Detailed knowledge of its genomic structure, transcriptional and post-transcriptional regulation and pharmacological modulation has underpinned the selection of NIS as an exciting approach for targeted gene delivery. A number of in vitro and in vivo studies have demonstrated the potential of using NIS gene therapy as a means of delivering highly conformal radiation doses selectively to tumours. This strategy is particularly attractive because it can be used with both diagnostic (99mTc, 125I, 124I)) and therapeutic (131I, 186Re, 188Re, 211At) radioisotopes and it lends itself to incorporation with standard treatment modalities, such as radiotherapy or chemoradiotherapy. In this article, we review the biology of NIS and discuss its development for gene therapy.
摘要
钠碘转运体（NIS）负责甲状腺、唾液腺、胃、肠和乳腺的碘摄取。它于 1996 年首次从大鼠中克隆出来，不久后从人和小鼠组织中克隆出来。在这期间，我们对 NIS 的生物学有了很多了解。对其基因组结构、转录和转录后调控以及药理学调节的详细了解为 NIS 作为靶向基因传递的一种令人兴奋的方法奠定了基础。许多体外和体内研究已经证明，使用 NIS 基因治疗作为向肿瘤选择性提供高适形辐射剂量的手段具有潜力。这种策略特别有吸引力，因为它可以与诊断（99mTc、125I、124I）和治疗（131I、186Re、188Re、211At）放射性同位素一起使用，并且可以与标准治疗方式（如放疗或放化疗）结合使用。本文综述了 NIS 的生物学特性，并讨论了其在基因治疗中的发展。
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