Powell Aidan, Hanna Colin, Sajjad Munawwar, Yao Rutao, Blum Kenneth, Gold Mark S, Quattrin Teresa, Thanos Panayotis K
Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Department of Pharmacology and Toxicology, Clinical Research Institute on Addictions, Jacobs School of Medicine and Biomedical Science, State University of New York at Buffalo, Buffalo, NY 14203, USA.
Department of Nuclear Medicine, University at Buffalo, Buffalo, NY 14214, USA.
J Pers Med. 2024 May 9;14(5):500. doi: 10.3390/jpm14050500.
Cocaine use is associated with negative health outcomes: cocaine use disorders, speedballing, and overdose deaths. Currently, treatments for cocaine use disorders and overdose are non-existent when compared to opioid use disorders, and current standard cocaine use disorder treatments have high dropout and recidivism rates. Physical exercise has been shown to attenuate addiction behavior as well as modulate brain activity. This study examined the differential effects of chronic cocaine use between exercised and sedentary rats. The effects of exercise on brain glucose metabolism (BGluM) following chronic cocaine exposure were assessed using Positron Emission Tomography (PET) and [18F]-Fluorodeoxyglucose (FDG). Compared to sedentary animals, exercise decreased metabolism in the SIBF primary somatosensory cortex. Activation occurred in the amygdalopiriform and piriform cortex, trigeminothalamic tract, rhinal and perirhinal cortex, and visual cortex. BGluM changes may help ameliorate various aspects of cocaine abuse and reinstatement. Further investigation is needed into the underlying neuronal circuits involved in BGluM changes and their association with addiction behaviors.
可卡因使用障碍、同时使用可卡因和海洛因以及过量死亡。目前，与阿片类药物使用障碍相比，针对可卡因使用障碍和过量的治疗方法并不存在，而且当前标准的可卡因使用障碍治疗方法存在高辍学率和复发率。体育锻炼已被证明可以减轻成瘾行为并调节大脑活动。本研究考察了运动大鼠和久坐大鼠长期使用可卡因后的不同影响。使用正电子发射断层扫描（PET）和[18F]-氟脱氧葡萄糖（FDG）评估长期接触可卡因后运动对脑葡萄糖代谢（BGluM）的影响。与久坐不动的动物相比，运动使体感诱发电位初级体感皮层的代谢降低。杏仁梨状和梨状皮层、三叉丘脑束、鼻周和梨周皮层以及视觉皮层出现激活。BGluM的变化可能有助于改善可卡因滥用和复吸的各个方面。需要进一步研究参与BGluM变化的潜在神经回路及其与成瘾行为的关联。
