D-环丝氨酸增强可卡因相关记忆的重新巩固。
D-cycloserine potentiates the reconsolidation of cocaine-associated memories.
作者信息
Lee Jonathan L C, Gardner Richard J, Butler Victoria J, Everitt Barry J
机构信息
Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, United Kingdom.
出版信息
Learn Mem. 2009 Jan 7;16(1):82-5. doi: 10.1101/lm.1186609. Print 2009 Jan.
Abstract
Conditioned cue-induced relapse to drug seeking is a major challenge to the treatment of drug addiction. It has been proposed that D-cycloserine might be useful in the prevention of relapse by reducing the conditioned reinforcing properties of drug-associated stimuli through facilitation of extinction. Here we show that intrabasolateral amygdala infusions of D-cycloserine in fact potentiate the reconsolidation of stimulus-cocaine memories to increase cue-induced relapse to drug seeking in rats with an extensive drug self-administration history. This elevation of cocaine seeking was correlated with an increase in the expression of the reconsolidation-associated gene zif268.
摘要
条件性线索诱导的觅药复吸是药物成瘾治疗面临的一项重大挑战。有人提出，D -环丝氨酸可能有助于预防复吸，其方式是通过促进消退来降低与药物相关刺激的条件性强化特性。在此我们表明，向基底外侧杏仁核内注射D -环丝氨酸实际上会增强刺激 - 可卡因记忆的重新巩固，从而增加有广泛药物自我给药史的大鼠的线索诱导觅药复吸。这种可卡因觅求行为的增加与重新巩固相关基因zif268表达的增加有关。
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