Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.
Ann N Y Acad Sci. 2010 Feb;1188:39-45. doi: 10.1111/j.1749-6632.2009.05081.x.
Signal transduction events are key modulators of cellular function and, in the cardiovascular system, an emerging role is played by phosphoinositide 3-kinases (PI3Ks), a family of enzymes containing a 3-phosphorylated phosphoinositide that produce lipid second messengers. In the heart, multiple PI3K isoforms are expressed, but play potentially distinct roles. Among cardiac PI3Ks, PI3Kalpha is triggered by tyrosine kinase receptors and plays a role in adaptive hypertrophy, while PI3Kgamma is triggered by G protein-coupled receptors and is involved in maladaptive heart remodeling. This view has been recently complicated by the finding that PI3Ks can also be involved in protein-protein interactions and affect signaling independently of their kinase activity. This review will thus focus on the effects of these multiple signaling events, with particular emphasis on their involvement in cardiac hypertrophy and failure.
信号转导事件是细胞功能的关键调节剂，在心血管系统中，磷酸肌醇 3-激酶（PI3Ks）发挥着新兴作用，它是一种含有 3-磷酸化磷酸肌醇的酶家族，可产生脂质第二信使。在心脏中，多种 PI3K 同工型表达，但可能发挥不同的作用。在心脏 PI3Ks 中，PI3Kalpha 被酪氨酸激酶受体触发，在适应性肥大中发挥作用，而 PI3Kgamma 被 G 蛋白偶联受体触发，参与适应性心脏重构。最近的发现使这种观点变得复杂，即 PI3Ks 也可以参与蛋白质-蛋白质相互作用，并独立于其激酶活性影响信号。因此，本综述将重点关注这些多种信号事件的影响，特别强调它们在心脏肥大和衰竭中的作用。
