Department of Medicine, Division of Gastroenterology, Duke University, Durham, NC 27710, USA.
Gastroenterol Clin North Am. 2010 Mar;39(1):57-68. doi: 10.1016/j.gtc.2009.12.001.
Obesity is associated with a spectrum of chronic liver disease. Because obesity increases the risk for advanced forms of liver disease (ie, cirrhosis and liver cancer), the obesity epidemic is emerging as a major factor underlying the burden of liver disease in the United States and many other countries. This article reviews mechanisms that mediate the pathogenesis of obesity-related liver disease, summarizes clinical evidence that demonstrates obesity-related liver disease can be life-threatening, and discusses whether or not treatments for obesity or related comorbidities impact liver disease outcomes.
肥胖与一系列慢性肝病有关。由于肥胖会增加晚期肝病（即肝硬化和肝癌）的风险，因此肥胖流行正在成为美国和许多其他国家肝病负担的主要因素。本文综述了介导肥胖相关肝病发病机制的机制，总结了表明肥胖相关肝病可能危及生命的临床证据，并讨论了治疗肥胖或相关合并症是否会影响肝病结局。
