Department of Dermatology, Peking University People's Hospital, No. 11 Xizhimen South Street, West District, Beijing 100044, People's Republic of China.
Int J Antimicrob Agents. 2010 Jun;35(6):550-2. doi: 10.1016/j.ijantimicag.2010.01.013. Epub 2010 Mar 3.
Disseminated infections caused by Trichosporon asahii are difficult to resolve. Combination regimens with synergistic drugs could provide additional options for treating trichosporonosis. The aim of this study was to evaluate the antifungal activities of voriconazole (VCZ), caspofungin (CAS) and amphotericin B (AMB) alone or in combination in vitro against clinical isolates of T. asahii. The combined antifungal activities of VCZ, CAS and AMB against 18 clinical isolates were assessed by a chequerboard microdilution method. CAS combined with AMB showed the highest percentage of synergistic effects (89%), much higher than those of the other two combinations (AMB/VCZ and CAS/VCZ both 17%). No antagonistic effect was observed in any case. This study demonstrates that the activity of two combined antifungals, especially the combination of CAS and AMB, against T. asahii is more effective than that of a drug alone against this fungus, suggesting that combined antifungal therapy may be a potential strategy for treating disseminated trichosporonosis.
由荚膜组织胞浆菌引起的播散性感染难以解决。具有协同作用的药物联合方案可为治疗毛孢子菌病提供更多选择。本研究旨在评估伏立康唑（VCZ）、卡泊芬净（CAS）和两性霉素 B（AMB）单独或联合体外对临床分离株荚膜组织胞浆菌的抗真菌活性。通过棋盘微量稀释法评估 VCZ、CAS 和 AMB 对 18 株临床分离株的联合抗真菌活性。CAS 联合 AMB 显示出最高的协同作用百分比（89%），明显高于其他两种组合（AMB/VCZ 和 CAS/VCZ 均为 17%）。在任何情况下均未观察到拮抗作用。本研究表明，两种联合抗真菌药物（尤其是 CAS 和 AMB 的联合）对荚膜组织胞浆菌的活性比单独使用一种药物对该真菌的活性更有效，这表明联合抗真菌治疗可能是治疗播散性毛孢子菌病的一种潜在策略。
