Department of Dermatology, Peking University People's Hospital, No. 11, Xizhimen South Street, West District, Beijing, 100044, People's Republic of China.
Mycopathologia. 2011 May;171(5):345-8. doi: 10.1007/s11046-010-9384-4. Epub 2010 Dec 14.
Treatment of disseminated trichosporosis is still challenging. Itraconazole is a widely used broad-spectrum antifungal drug. In vitro interactions of itraconazole (ICZ) with amphotericin B (AMB), caspofungin (CAS), and terbinafine (TBF) against 18 clinical isolates of Trichosporon asahii were assessed by chequerboard microdilution method. ICZ combined with CAS showed the highest percentage of synergistic effect (72.2%), followed by ICZ/AMB (11%) and ICZ/TBF (11%) combination. Antagonistic effect was not observed. This study demonstrates that itraconazole can enhance the antifungal activity of CAS against T. asahii, suggesting that this combination may be a potential strategy for treating disseminated trichosporosis.
播散性毛孢子菌病的治疗仍然具有挑战性。伊曲康唑是一种广泛应用的广谱抗真菌药物。采用棋盘微量稀释法评估了伊曲康唑（ICZ）与两性霉素 B（AMB）、卡泊芬净（CAS）和特比萘芬（TBF）体外对 18 株临床分离的新生隐球菌的相互作用。ICZ 联合 CAS 显示出最高的协同作用百分率（72.2%），其次是 ICZ/AMB（11%）和 ICZ/TBF（11%）联合。未观察到拮抗作用。本研究表明伊曲康唑可以增强 CAS 对 T. asahii 的抗真菌活性，提示这种联合可能是治疗播散性毛孢子菌病的一种潜在策略。
