Department of Physics, Fujian Key Laboratory of Plasma and Magnetic Resonance, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, China.
J Magn Reson. 2010 May;204(1):82-90. doi: 10.1016/j.jmr.2010.02.005. Epub 2010 Feb 12.
Recently ultrafast techniques enable 2D NMR spectra to be obtained in a single scan. They have been successfully applied for 2D COSY, TOCSY, DOSY, HMQC, and J-resolved spectra. In this paper, two alternative ultrafast 2D COSY methods (g-COSY and gDQF-COSY) based on continuous constant-time phase-modulated spatial encoding were proposed. Theoretical expressions of the resulting signals were deduced. Experiments were performed to verify our theoretical analysis and the feasibility of the methods. Comparisons between the experimental results of our methods and those of the previous real-time phase-modulated spatial encoding method demonstrate that the signal-to-noise ratio and resolution of the 2D COSY spectra are improved, and a good 2D COSY spectrum is easier to achieve by using our methods.
最近，超快技术使得在单次扫描中获得二维 NMR 谱成为可能。这些技术已成功应用于二维 COSY、TOCSY、DOSY、HMQC 和 J 分辨谱。本文提出了两种基于连续恒时相位调制空间编码的超快二维 COSY 方法（g-COSY 和 gDQF-COSY）。推导了所得信号的理论表达式。进行了实验以验证我们的理论分析和方法的可行性。我们的方法与以前的实时相位调制空间编码方法的实验结果进行了比较，结果表明，二维 COSY 谱的信噪比和分辨率得到了提高，并且使用我们的方法更容易获得良好的二维 COSY 谱。
