Laboratoire ACTES, UPRES EA 3596, Departement de Physiologie, Université des Antilles et de la Guyane, Campus de Fouillole, Pointe-à-Pitre, Guadeloupe.
Clin Hemorheol Microcirc. 2010;44(2):107-14. doi: 10.3233/CH-2010-1258.
Abnormal hemorheology has been proposed previously as a possible genesis of exercise-induced hypoxemia (EIH) in humans. This study, in support of the hemorheological hypothesis, aims at determining if red blood cell shape changes might be related to EIH. Three groups of subjects: one without EIH (n=5); one developing mild-EIH (n=7); and, one with moderate EIH (n=5). Each group performed a progressive and maximal exercise test on cycle-ergometer. We evaluated the percent of stomatocytes, echinocytes and schizocytes in blood smears prepared from phlebotomy samples taken at rest and at maximal exercise. The percent of schizocytes or stomatocytes was not different between the three EIH groups at rest; and, exercise produced no change from the resting values of those cell types. The percent of echinocytes was not different between the three EIH groups at rest, however, exercise significantly increased the percent of echinocytes from the resting value of both the mild- and moderate-EIH groups, while the non-EIH group remained unchanged. We suggested that the rigidity of echinocytes could have contributed to the genesis of EIH.
先前有研究提出异常的血液流变学可能是导致人体运动性低氧血症（EIH）的原因之一。本研究旨在支持血液流变学假说，以确定红细胞形态变化是否与 EIH 有关。研究共纳入三组研究对象：一组无 EIH（n=5），一组发生轻度 EIH（n=7），一组发生中度 EIH（n=5）。每组研究对象均进行递增负荷和最大运动测试。我们评估了取自休息和最大运动状态下的静脉血样制备的血涂片上的棘形红细胞、口形红细胞和裂红细胞的比例。在休息状态下，三组 EIH 患者的棘形红细胞和口形红细胞比例无差异；且运动并未导致这些细胞类型的比例与休息时相比发生改变。在休息状态下，三组 EIH 患者的棘形红细胞比例无差异，但运动使轻度和中度 EIH 组的棘形红细胞比例与休息时相比显著增加，而非 EIH 组则保持不变。我们认为棘形红细胞的刚性可能促成了 EIH 的发生。
