Department of Physical Therapy, Catholic University of Daegu, Daegu, Republic of Korea.
NeuroRehabilitation. 2010;26(2):95-103. doi: 10.3233/NRE-2010-0540.
Failure of early motor learning due to damage in any brain area involved in this process may interfere with successful rehabilitation of such patients.
We investigated the changes in activation of the motor network during sequential finger motor learning to delineate the characteristics of the cortico-subcortical network during motor skill learning.
Twenty healthy, right-handed volunteers participated. Subjects were instructed to perform eight blocks of a sequential finger motor task while functional MRI (fMRI) was performed.
The participants had an improvement in performance over time from block 1 to block 4, indicating that successful learning had occurred, followed by a plateau from block 5 to the last block. On fMRI, activities of the contralateral primary sensorimotor cortex, the premotor cortex, the supplementary motor area, and the posterior parietal cortex gradually increased from block 1 to block 4 and then decreased from block 5 to the last. In contrast, activity of the ipsilateral cerebellum showed a linear increase spanning the last block with peak activation. The thalamus and basal ganglia showed unilateral or bilateral activities at the unique stage of motor learning.
These findings delineated the characteristic plastic changes and different roles of the cortico-subcortical network during the early phase of motor learning and automatization.
由于任何参与该过程的脑区受损导致早期运动学习失败，可能会干扰此类患者的成功康复。
我们研究了运动网络在顺序手指运动学习过程中的激活变化，以描绘运动技能学习过程中皮质-皮质下网络的特征。
20 名健康、右利手的志愿者参与了本研究。在进行功能磁共振成像（fMRI）的同时，指导受试者完成 8 个连续手指运动任务块。
参与者在从第 1 块到第 4 块的时间内表现出逐渐提高的趋势，表明成功学习已经发生，随后从第 5 块到最后一块出现平台期。在 fMRI 上，对侧初级感觉运动皮层、运动前皮层、辅助运动区和后顶叶皮层的活动从第 1 块到第 4 块逐渐增加，然后从第 5 块到最后一块减少。相比之下，对侧小脑的活动在最后一块呈现出线性增加，并达到峰值激活。丘脑和基底节在运动学习的独特阶段表现出单侧或双侧活动。
这些发现描绘了皮质-皮质下网络在运动学习和自动化的早期阶段的特征性的可塑性变化和不同作用。
