白细胞介素-10 水平与缺血性脑卒中预后的关系。
Link between interleukin-10 level and outcome after ischemic stroke.
机构信息
Division of Basic Medical Science, Department of Nursing, Meiho Institute of Technology, Ping Tung, Taiwan, ROC.
出版信息
Neuroimmunomodulation. 2010;17(4):223-8. doi: 10.1159/000290038. Epub 2010 Mar 5.
OBJECTIVES
The prognostic value of interleukin (IL)-10 in patients after acute ischemic stroke (IS) is not well understood. This study tested the hypothesis that serum levels of IL-10 are substantially increased after IS and predictive of IS outcome.
METHODS
Serum IL-10 levels were examined 48 h after acute IS in 135 consecutive patients, and in 20 healthy and 30 at-risk controls.
RESULTS
Mean serum IL-10 was significantly higher in IS patients than in both control groups (p < 0.0001, respectively). Additionally, serum IL-10 was significantly higher in patients with severe neurological impairment [defined as a score >or=12 on the National Institute of Health Stroke Scale (NIHSS)] than in patients with less severe neurological impairment (NIHSS score <12) 48 h after IS (p < 0.0001). Furthermore, higher serum IL-10 was strongly and independently correlated with severe neurological impairment (NIHSS >or=12) 48 h after acute IS (p < 0.0001), and independently predictive of combined major adverse clinical outcomes (defined as recurrent IS, any cause of death or NIHSS >or=12) on day 90 following IS (p < 0.0001).
CONCLUSIONS
Serum IL-10 is an independent prognosticator of IS outcome.
目的
白细胞介素（IL）-10 在急性缺血性脑卒中（IS）患者中的预后价值尚不清楚。本研究旨在验证血清 IL-10 水平在 IS 后显著升高并可预测 IS 结局的假设。
方法
在 135 例连续急性 IS 患者和 20 例健康对照者及 30 例高危对照者中，检测了 48 小时后血清 IL-10 水平。
结果
与两组对照组相比，IS 患者的平均血清 IL-10 水平显著升高（分别为 p < 0.0001）。此外，IS 后 48 小时，神经功能严重受损患者（定义为国立卫生研究院卒中量表（NIHSS）评分≥12）的血清 IL-10 显著高于神经功能损伤较轻的患者（NIHSS 评分 <12）（p < 0.0001）。此外，较高的血清 IL-10 与 IS 后 48 小时的严重神经功能损伤（NIHSS >or=12）强烈且独立相关（p < 0.0001），并且可独立预测 IS 后 90 天的联合主要不良临床结局（定义为复发 IS、任何原因死亡或 NIHSS >or=12）（p < 0.0001）。
结论
血清 IL-10 是 IS 结局的独立预后指标。
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