血清中新蝶呤水平及其在缺血性脑卒中患者中的预后价值。
Serum level and prognostic value of neopterin in patients after ischemic stroke.
机构信息
Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
出版信息
Clin Biochem. 2012 Dec;45(18):1596-601. doi: 10.1016/j.clinbiochem.2012.07.113. Epub 2012 Aug 8.
BACKGROUND
We hypothesized that serum level of neopterin is significantly predictive of prognostic outcome in patients after acute ischemic stroke (IS).
METHODS
Between November 2008 and May 2010, serum levels of neopterin were prospectively collected at 48 h after acute IS in 157 patients.
RESULTS
Serum neopterin levels were substantially higher in patients with severe neurological impairment [National institutes of Health Stroke Scale (NIHSS) score ≥12] than in those with NIHSS <12 (p<0.008). Furthermore, Spearman's test showed a strongly positive correlation between neopterin level and NIHSS (p=0.003). Multiple logistic regression analysis demonstrated that serum neopterin level was strongly and independently predictive of NIHSS ≥12 (p=0.002) at 48 h after acute IS and 90-day major adverse clinical outcome (defined as NIHSS≥12, recurrent stroke or death) (p=0.003).
CONCLUSION
Serum level of neopterin was notably increased after acute IS. This biomarker was strongly and independently predictive of 90-day unfavorable clinical outcome in patients after acute IS.
背景
我们假设，在急性缺血性脑卒中（IS）患者中，血清中新蝶呤的水平对预后结局有显著的预测作用。
方法
在 2008 年 11 月至 2010 年 5 月期间，在 157 例急性 IS 患者发病 48 小时后，前瞻性地采集了血清中新蝶呤的水平。
结果
与 NIHSS 评分＜12 的患者相比，神经功能严重受损（NIHSS 评分≥12）的患者的血清新蝶呤水平显著更高（p＜0.008）。此外，Spearman 检验显示新蝶呤水平与 NIHSS 之间存在强烈的正相关（p=0.003）。多元逻辑回归分析表明，在急性 IS 后 48 小时，血清新蝶呤水平与 NIHSS≥12（p=0.002）以及 90 天主要不良临床结局（定义为 NIHSS≥12、复发性卒中或死亡）（p=0.003）显著相关。
结论
急性 IS 后，血清中新蝶呤的水平显著升高。该生物标志物能显著且独立地预测急性 IS 患者 90 天的不良临床结局。
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