Edvinsson L, Ekman R, Jansen I, McCulloch J, Mortensen A, Uddman R
Department of Internal Medicine, University of Lund, Sweden.
Neurosci Lett. 1991 Jan 2;121(1-2):151-4. doi: 10.1016/0304-3940(91)90672-g.
Human cerebral vessels were found to contain calcitonin gene-related peptide (CGRP)-like immunoreactivity (-LI) which in the reversed phase HPLC co-eluted with authentic human alpha-CGRP. The level was significantly lower in arteries removed from patients who had died from a subarachnoid haemorrhage (SAH) as compared to patients who died of a coronary infarction. On a molar basis human alpha-CGRP was more potent than human beta-CGRP to dilate human brain vessels and to dilate vasoconstriction elicited by whole blood. It is suggested that the trigemino-cerebrovascular system storing CGRP-LI may be involved in the pathophysiology of SAH in man.
人们发现人类脑血管含有降钙素基因相关肽（CGRP）样免疫反应性物质（-LI），在反相高效液相色谱法中，其与真实的人类α-CGRP共洗脱。与死于冠状动脉梗死的患者相比，死于蛛网膜下腔出血（SAH）的患者所切除动脉中的该物质水平显著降低。以摩尔为基础，人类α-CGRP在扩张人类脑血管以及扩张全血引起的血管收缩方面比人类β-CGRP更有效。有人提出，储存CGRP-LI的三叉神经-脑血管系统可能参与了人类SAH的病理生理学过程。
