Juul R, Edvinsson L, Gisvold S E, Ekman R, Brubakk A O, Fredriksen T A
Department of Neurosurgery, University Hospital of Trondheim, Sweden.
Br J Neurosurg. 1990;4(3):171-9. doi: 10.3109/02688699008992720.
Calcitonin gene-related peptide (CGRP) is a neurotransmitter candidate together with the tachykinins in sensory fibres in the cerebral vasculature, with possible vasodilating properties. The origin of most of the CGRP-immunoreactive cerebrovascular nerve fibres seems to be the trigeminal ganglion. Experimentally produced vasoconstriction in cats after lesions of the trigeminal ganglion have shown marked prolonged constriction compared to controls. The possible involvement of the trigemino-cerebrovascular system as a defence system, with CGRP probably being the more potent vasodilatator, was investigated in 12 patients with subarachnoid haemorrhage (SAH). After operation with clipping of the aneurysm and treatment according to department policy, blood samples were taken from the external jugular vein on postoperative days 1, 2, 3, 5, 7, 9, frozen and analysed (radioimmunoassay) for CGRP-LI (-like immunoreactivity) levels. The patients were monitored with Doppler recordings from the middle cerebral arteries (MCA) and internal carotid arteries (ICA) following blood sampling. The relationship Vmean MCA/V mean ICA was used as an index of vasospasm. The highest CGRP-LI levels were found in the patient with highest velocities/index values. In patients with MCA aneurysms (n = 7), a correlation of r = 0.61 was found between the index and CGRP-LI levels. However, significant changes in the group as a whole was not found. The possible involvement of the trigemino-cerebrovascular system in SAH is discussed.
降钙素基因相关肽（CGRP）是一种神经递质候选物，与脑血管感觉纤维中的速激肽一起，可能具有血管舒张特性。大多数CGRP免疫反应性脑血管神经纤维似乎起源于三叉神经节。实验性地在猫的三叉神经节损伤后引起血管收缩，结果显示与对照组相比，收缩明显延长。在12例蛛网膜下腔出血（SAH）患者中，研究了三叉神经脑血管系统作为一种防御系统的可能作用，其中CGRP可能是更有效的血管舒张剂。在按照科室政策进行动脉瘤夹闭手术并治疗后，于术后第1、2、3、5、7、9天从颈外静脉采集血样，冷冻后进行分析（放射免疫测定），以检测CGRP-LI（类免疫反应性）水平。在采血后，用多普勒记录大脑中动脉（MCA）和颈内动脉（ICA）对患者进行监测。Vmean MCA/V mean ICA的关系被用作血管痉挛的指标。在速度/指数值最高的患者中发现了最高的CGRP-LI水平。在患有MCA动脉瘤的患者（n = 7）中，指数与CGRP-LI水平之间的相关性为r = 0.61。然而，未发现整个组有显著变化。本文讨论了三叉神经脑血管系统在SAH中的可能作用。
