Lefauconnier J M, Bouchaud C, Bernard G
INSERM U 26, Hôpital Fernand Widal, Paris, France.
Neurosci Lett. 1991 Jan 2;121(1-2):9-11. doi: 10.1016/0304-3940(91)90636-8.
Pathways taken by peripherally administered small molecules when entering the brain were investigated in 6-day-old rats by radioautography and fluorescence microscopy after intravenous administration and rapid freezing. L-[U-14C]Phenylalanine, [U-14C]sucrose and sodium fluorescein reached the brain within less than 5 seconds. These blood-borne molecules were found in the subarachnoid cisterns and the superficial parenchyma. These results suggest a special permeability of the arachnoid layer and/or the pial vessels. Phenylalanine alone reached the deep parenchyma because of the existence of a specific endothelial carrier.
通过放射自显影和荧光显微镜技术，在静脉注射并快速冷冻后，对6日龄大鼠外周给予小分子进入大脑的途径进行了研究。L-[U-14C]苯丙氨酸、[U-14C]蔗糖和荧光素钠在不到5秒内就进入了大脑。这些血源分子存在于蛛网膜下池和浅表实质中。这些结果表明蛛网膜层和/或软脑膜血管具有特殊的通透性。由于存在特定的内皮载体，仅苯丙氨酸进入了深部实质。
