伴有白细胞破碎性血管炎的超敏性血管炎与α-1蛋白酶抑制剂相关。

Hypersensitivity vasculitis with leukocytoclastic vasculitis associated with alpha-1-proteinase inhibitor.

作者信息

Mwirigi Nicola W, Thomas Charles F

机构信息

Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care and Internal Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

出版信息

Case Rep Med. 2009;2009:941258. doi: 10.1155/2009/941258. Epub 2010 Feb 24.

DOI:10.1155/2009/941258

PMID:20204065

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2829622/

Abstract

Prolastin is a commercially available form of alpha-1-antitrypsin (AAT) that is derived from pooled human plasma and used for treatment of severe alpha-1-antitrypsin deficiency (AATD). We describe a patient with AATD who developed presumed hypersensitivity vasculitis (HV) following a Prolastin infusion. Hypersensitivity vasculitis (HV), or cutaneous vasculitis, is characterized by inflammation of the small vessels of the skin with resultant ischemia to the distally supplied areas. To our knowledge, this is the first reported case of presumed hypersensitivity vasculitis following Prolastin infusion.

摘要

普洛莱斯坦是一种市售的α-1抗胰蛋白酶（AAT）制剂，它源自混合人血浆，用于治疗严重的α-1抗胰蛋白酶缺乏症（AATD）。我们描述了一名患有AATD的患者，在输注普洛莱斯坦后发生了疑似超敏性血管炎（HV）。超敏性血管炎（HV），即皮肤血管炎，其特征是皮肤小血管炎症，导致远端供血区域缺血。据我们所知，这是首例输注普洛莱斯坦后发生疑似超敏性血管炎的报告病例。