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[危重症中的营养与贫血]

[Nutrition and anaemias in critical illness].

作者信息

Gallardo F, Gallardo García Manuel Blas, Cabra M J, Curiel E, Arias M D, Muñoz A, Aragón C

机构信息

Servicio de Angiología y Cirugía vascular, Hospital Universitario Juan Canalejo, La Coruña, España.

出版信息

Nutr Hosp. 2010 Jan-Feb;25(1):99-106.

Abstract

INTRODUCTION

We made a clinical study, about nutrition in seriously ill patients, which includes a typical heterogeneous group of critical ill patients, with/without anaemia's, that have been admitted to Intensive Care Unit, ICU. It is difficult to individualize and to generalize the relative importance of all the factors that can contribute to these anaemia's in the admission to the Unit, including nutritional deficiencies, inflammatory alterations, the immune response to aggressions, inmunitary modifications and the complex relations existing between these clinic processes.

OBJECTIVE

Indirect valuation of the nutritional situation and anaemia's, in a typical heterogeneous group of critical ill patients.

METHOD/RESULTS: We studied 202 patients admitted to ICU, of varied and heterogeneous origin, classifying them in 3 groups: control, post surgery and septic group's, becoming the indirect valuation of the nutritional situation on the basis of: Global Subjective Valuation, (VGS) and the nutritional analytical determinations of total lymphocytes, albumin, and transferrin. Also we made hemogram and determinations of sideremia and ferritinemia to all of them. In 57% of the patients, we observed levels haemoglobin < 12.5 g/dl, basically in the post surgery groups, 68 patients and septic group's, 10 patients. And with levels haemoglobin < 10 g/dl, in 25 patient's (12.3%). There were 87 patients, 23 of them in the control group's, 58 in the post surgery and 5 septic group's, with levels haemoglobin > 12.5 g/dl. Regarding the nutritional prognoses indicators, (VGS + nutritional profile), in the control group's, they did not present anaemia nor analytical clinical under nourishment, in the post surgery group's, anaemia and slight under nourishment and in the septic group's, anaemia and moderate under nourishment. There were significant differences between the surgery and septic group and control group's, in values of haemoglobin, iron, total lymphocytes, transferrin and albumin. A statistical correlation between sideremia and albumin was significative. (Spearman's Rho 0,277).

CONCLUSIONS

The evaluation of the anaemia and nutritional valuation. and the ferroterapic treatment, as immune-nutrient, can be beneficial for the integrity of the immune system and its defense's abilities against the aggressions in critically ills.

摘要

引言

我们针对重症患者的营养状况开展了一项临床研究,该研究纳入了一组典型的重症患者,他们患有或未患有贫血,均入住了重症监护病房(ICU)。在这些患者入住ICU时,很难针对所有可能导致贫血的因素进行个体化分析和归纳其相对重要性,这些因素包括营养缺乏、炎症改变、对侵袭的免疫反应、免疫调节以及这些临床过程之间存在的复杂关系。

目的

对一组典型的重症异质性患者的营养状况和贫血情况进行间接评估。

方法/结果:我们研究了202例入住ICU的患者,他们来源各异且具有异质性,将其分为3组:对照组、术后组和脓毒症组。基于整体主观评估(VGS)以及对总淋巴细胞、白蛋白和转铁蛋白的营养分析测定,对营养状况进行间接评估。我们还对所有患者进行了血常规检查以及血清铁和铁蛋白水平的测定。在57%的患者中,我们观察到血红蛋白水平<12.5 g/dl,主要出现在术后组(68例)和脓毒症组(10例)。血红蛋白水平<10 g/dl的患者有25例(12.3%)。有87例患者血红蛋白水平>12.5 g/dl,其中对照组23例,术后组58例,脓毒症组5例。关于营养预后指标(VGS + 营养状况),对照组既无贫血也无临床分析意义上的营养不良,术后组有贫血和轻度营养不良,脓毒症组有贫血和中度营养不良。手术组和脓毒症组与对照组在血红蛋白、铁、总淋巴细胞、转铁蛋白和白蛋白值方面存在显著差异。血清铁与白蛋白之间存在显著的统计相关性(斯皮尔曼等级相关系数为0.277)。

结论

对贫血和营养状况的评估以及作为免疫营养剂的铁剂治疗,可能有益于重症患者免疫系统的完整性及其抵御侵袭的防御能力。

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