Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan.
Adv Exp Med Biol. 2010;662:213-8. doi: 10.1007/978-1-4419-1241-1_30.
To determine the alterations in optical characteristics and cerebral blood oxygenation (CBO) in the frontal lobe during language tasks, we evaluated the changes in mean optical pathlength (MOP) and CBO induced by a verbal fluency task (VFT) in the right and left frontal lobes in normal adults (n = 9, mean age = 29.6 +/- 4.8 years). We employed a newly developed 8-channel time-resolved near-infrared spectroscopy (TRS) instrument. The results demonstrated differences in MOP in the fronto-temporal areas with subject and wavelength; however, there was no significant difference between the right and left sides (p > 0.05). Also, the VFT did not affect the MOP significantly as compared to that before the tasks (p > 0.05). In all of the recording regions, the VFT caused increases in concentration of oxyhemoglobin and total hemoglobin associated with a decrease in deoxyhemoglobin concentration, indicating that these cortical areas were activated by the VFT. However, the mean concentration changes of oxyhemoglobin and total hemoglobin on the left side were larger than those on the right side. In addition, functional MRI demonstrated that the inferior frontal gyrus on the left side was activated in the subjects who exhibited increases in oxyhemoglobin concentration in these areas. These results suggest that TRS may be useful to study language function and to assess hemispheric dominance for language.
为了确定在语言任务过程中额叶中的光学特性和脑血氧饱和度（CBO）的变化，我们评估了正常成年人（n=9，平均年龄为 29.6±4.8 岁）右和左额叶中言语流畅性任务（VFT）引起的平均光程（MOP）和 CBO 的变化。我们采用了新开发的 8 通道时间分辨近红外光谱（TRS）仪器。结果表明，MOP 在额颞区域存在个体和波长差异，但两侧之间无显著差异（p>0.05）。此外，与任务前相比，VFT 对 MOP 的影响不显著（p>0.05）。在所有记录区域，VFT 引起与去氧血红蛋白浓度降低相关的氧合血红蛋白和总血红蛋白浓度的增加，表明这些皮质区域被 VFT 激活。然而，左侧的氧合血红蛋白和总血红蛋白的平均浓度变化大于右侧。此外，功能磁共振成像显示，在这些区域中氧合血红蛋白浓度增加的受试者中，左侧的额下回被激活。这些结果表明，TRS 可能有助于研究语言功能并评估语言的优势半球。
