Hu Yiwei, Sun Xuelu, Guo Chen, Wu Ruiyun, Dou Jiahao, Song Shoufang, Guo Fanshun, Wei Jin
Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Clinical Research Center for Endemic Disease of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Front Aging Neurosci. 2024 Dec 18;16:1465310. doi: 10.3389/fnagi.2024.1465310. eCollection 2024.
Although previous research has substantiated lifestyle and cardiovascular-related measures have some impact on cognitive function, studies focusing on the correlation between Life's Essential 8 (LE8), an indicator for quantifying cardiovascular health (CVH), and cognitive function are limited. Consequently, this study sought to explore the potential link between CVH and cognitive function as well as to determine if depressive states mediated the relationship.
A total of 2,263 individuals were selected from the 2011-2014 National Health and Nutrition Examination Survey (NHANES). Post-averaged LE8 scores was classified as low CVH (0-49), moderate CVH (50-79), and high CVH (80-100) according to the American Heart Association (AHA). Cognitive function was evaluated using the Animal Fluency Test (AFT), the Digit Symbol Substitution Test (DSST), the instant recall test (IRT), and the delayed recall test (DRT). The Z-score is figured by subtracting the average of the scores of four test sections and dividing by the standard deviation. Models of multi-variable linear regression were employed to appraise the relationships between CVH and the Z-score for cognitive function. Depression was assessed through the utilization of the Patient Health Questionnaire (PHQ-9). Points of 10 or above indicated a positive diagnosis. Weighted linear regression and restricted cubic spline (RCS) were employed to evaluate the correlation between CVH and cognitive function. Pearson's test was utilized to explore the interrelation among primary variables and mediated effects analyses of depressive states.
A significant positive linear relationship was observed between LE8 score and cognitive function Z-score. In all models, there was a positive correlation between higher Z-score for cognitive function and every ten points added to the LE8 score, which evaluates CVH. The findings of the mediating effect study indicated that the effects of cardiovascular health on cognitive function were partially mediated by depression.
Results showed a meaningful positive linear correlation between the level of CVH and cognitive function, with a mediating role for depression. These results accentuate the significance of sustaining high CVH and avoiding depression to improve cognitive functioning.
尽管先前的研究证实生活方式和心血管相关措施对认知功能有一定影响，但关注量化心血管健康（CVH）的指标“生命基本八项”（LE8）与认知功能之间相关性的研究有限。因此，本研究旨在探讨CVH与认知功能之间的潜在联系，并确定抑郁状态是否介导了这种关系。
从2011 - 2014年美国国家健康与营养检查调查（NHANES）中选取了2263名个体。根据美国心脏协会（AHA）的标准，将平均后的LE8得分分为低CVH（0 - 49）、中度CVH（50 - 79）和高CVH（80 - 100）。使用动物流畅性测试（AFT）、数字符号替换测试（DSST）、即时回忆测试（IRT）和延迟回忆测试（DRT）评估认知功能。Z分数通过减去四个测试部分得分的平均值并除以标准差来计算。采用多变量线性回归模型评估CVH与认知功能Z分数之间的关系。通过使用患者健康问卷（PHQ - 9）评估抑郁情况。得分10分及以上表明诊断为阳性。采用加权线性回归和受限立方样条（RCS）评估CVH与认知功能之间的相关性。使用Pearson检验探索主要变量之间的相互关系以及抑郁状态的中介效应分析。
观察到LE8得分与认知功能Z分数之间存在显著的正线性关系。在所有模型中，评估CVH的LE8得分每增加10分，认知功能的Z分数就越高，二者呈正相关。中介效应研究结果表明，心血管健康对认知功能的影响部分由抑郁介导。
结果显示CVH水平与认知功能之间存在有意义的正线性相关性，抑郁起中介作用。这些结果强调了维持高CVH水平和避免抑郁对改善认知功能的重要性。
