Rauch A M, Glode M P, Wiggins J W, Rodriguez J G, Hopkins R S, Hurwitz E S, Schonberger L B
Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
Pediatrics. 1991 May;87(5):663-9.
Between October 1984 and January 1985, the largest outbreak of Kawasaki syndrome reported to date in the continental United States (62 cases) occurred in the Front Range of the Rocky Mountains, extending from Colorado Springs, Colorado, to Cheyenne, Wyoming. Fifty-two (84%) of these Kawasaki syndrome patients lived in the Denver metropolitan area. A case-control study revealed that 16 (62%) of 26 Kawasaki syndrome patients compared with 10 (20%) of 49 matched control subjects had a history of exposure to shampooed (19%) or spot-cleaned (81%) rugs or carpets within 30 days of the Kawasaki syndrome onset date (odds ratio = 5, P less than .01). The time of exposure to shampooed or spot-cleaned rugs or carpets for 9 of 10 Kawasaki syndrome patients who had a single exposure and for all 6 Kawasaki syndrome patients who had multiple exposures were clustered within an interval 13 to 30 days before the onset of illness. Although the reason for this unusually large outbreak remains obscure, it is the third in which a statistically significant association between Kawasaki syndrome and rug or carpet cleaning has been found.
1984年10月至1985年1月期间，美国大陆迄今报告的最大规模川崎病暴发（62例）发生在落基山脉的前缘地带，从科罗拉多州的科罗拉多斯普林斯延伸至怀俄明州的夏延。这些川崎病患者中有52例（84%）居住在丹佛都会区。一项病例对照研究显示，26例川崎病患者中有16例（62%），而49名匹配的对照对象中有10例（20%）在川崎病发病日期前30天内有接触过用洗发水清洗过（19%）或局部清洁过（81%）的地毯或小毛毯的经历（优势比=5，P<0.01）。10例有单次接触经历的川崎病患者中的9例以及所有有多次接触经历的6例川崎病患者，接触用洗发水清洗过或局部清洁过的地毯或小毛毯的时间集中在发病前13至30天的时间段内。尽管此次异常大规模暴发的原因仍不明朗，但这是第三次发现川崎病与地毯或小毛毯清洁之间存在统计学显著关联。
