Pérez-Macho L, Borja-Andrés S
Hospital Virgen de la Concha, Zamora, España.
Rev Neurol. 2010 Feb 8;50 Suppl 2:S55-8.
Constipation and gastric atony are two of the most important non-motor symptoms of the disease. The first is made significant by its high prevalence and precocity, since it may appear several years before the motor symptoms, and the second because of the repercussions it has on the absorption of oral medication used in this disease.
Both the symptoms and their possible treatment are reviewed.
In both cases treatment is based on hygienic-dietary measures that avoid substances that reduce peristalsis, prokinetic drugs like domperidone and, sometimes, infiltration of botulinum toxin, electrical stimulation or even surgical treatment.
便秘和胃无力是该疾病最重要的两种非运动症状。前者因其高发病率和早熟而显著,因为它可能在运动症状出现前数年就出现,而后者则因其对该疾病口服药物吸收的影响。
对症状及其可能的治疗方法进行了综述。
在这两种情况下,治疗都基于卫生饮食措施,即避免使用减少蠕动的物质、使用多潘立酮等促动力药物,有时还包括肉毒杆菌毒素注射、电刺激甚至手术治疗。