González-Fernández J, Prieto-Albin R, Velasco-Palacios L, Jorge-Roldán S, Cubo-Delgado E
Hospital General Yagüe, Burgos, España.
Rev Neurol. 2010 Feb 8;50 Suppl 2:S51-4.
The non-motor symptoms of Parkinson's disease are a frequent and often under-diagnosed disorder. Two of the most significant non-motor symptoms are perhaps dysphagia and sialorrhea (which are relatively common in advanced stages of the disease) owing to their important functional repercussions and to the associated comorbidity.
In recent years, different evaluation scales have been developed for clinical use and in screening the aforementioned symptoms. Of the different therapeutic options available, botulinum toxin represents the preferred treatment for sialorrhea. In contrast, speech therapy and an optimisation of the antiparkinsonian therapy are generally useful measures to treat dysphagia, percutaneous endoscopic gastrostomy being reserved for patients suffering from Parkinson who have severe dysphagia.
帕金森病的非运动症状是一种常见且常常诊断不足的病症。吞咽困难和流涎（在疾病晚期相对常见）可能是两个最重要的非运动症状，因为它们具有重要的功能影响以及相关的合并症。
近年来，已开发出不同的评估量表用于临床及筛查上述症状。在现有的不同治疗选择中，肉毒杆菌毒素是治疗流涎的首选疗法。相比之下，言语治疗和优化抗帕金森病治疗通常是治疗吞咽困难的有效措施，经皮内镜下胃造口术则适用于患有严重吞咽困难的帕金森病患者。
