从Serratula wolffii 的根部中分离得到的新型蜕皮甾体的结构和立体化学。

Structure and stereochemistry of novel ecdysteroids from the roots of Serratula wolffii.

机构信息

Department of Pharmaceutical Chemistry, Semmelweis University, Högyes Endre utca 9, H-1092 Budapest, Hungary.

出版信息

Magn Reson Chem. 2010 May;48(5):386-91. doi: 10.1002/mrc.2581.

PMID:20205207

Abstract

Three new natural ecdysteroids viz. 22-dehydro-20-deoxy-ajugasterone C (1), 1-hydroxy-22-deoxy-20,21-didehydro-ecdysone (2) and 22-deoxy-20,21-didehydro-ecdysone (3) were isolated from the methanol extract of the roots of Serratula wolffii. The structures of compounds 1-3 were established by various spectroscopic techniques, including one- and two-dimensional NMR, circular dichroism and mass spectroscopic methods.

摘要

从苦荬菜的甲醇提取物中分离得到三种新的天然蜕皮甾酮，分别为 22-去氢-20-脱氧 ajugasterone C（1）、1-羟基-22-去氧-20,21-二脱氢-蜕皮甾酮（2）和 22-去氧-20,21-二脱氢-蜕皮甾酮（3）。通过各种光谱技术，包括一维和二维 NMR、圆二色性和质谱方法，确定了化合物 1-3 的结构。