HLA-DRB1 等位基因多态性与白塞病的相关性研究。

Study on association between polymorphism of HLA-DRB1 alleles and Behçet's disease.

机构信息

Department of Dermatology, No 1 Affiliated Hospital of China Medical University, Shenyang, China.

出版信息

J Eur Acad Dermatol Venereol. 2009 Dec;23(12):1419-22. doi: 10.1111/j.1468-3083.2009.03335.x.

DOI:10.1111/j.1468-3083.2009.03335.x

PMID:20205319

Abstract

BACKGROUND

Behçet's disease (BD) is known to be associated with human leucocyte antigen (HLA)-B*51 in many ethnic groups. However, the association of HLA class II gene with BD has been described to be different according to different countries and regions.

OBJECTIVE

This study aims to investigate the association between polymorphism of HLA-DRB1 alleles and BD.

METHODS

Forty patients with BD and 100 healthy controls were typed for HLA-DRB1 alleles by the LABType SSO method.

RESULTS

The frequency of HLA-DRB114 was significantly higher in BD patients than in controls (P < 0.05), while the frequency of HLA-DRB115 was markedly lower in BD patients (P < 0.05). Regarding clinical manifestations, the frequency of HLA-DRB115 was significantly decreased in BD patients with genital ulcerations compared with controls (P < 0.05); the frequency of HLA-DRB114 was significantly increased in BD patients with erythema nodosum-like lesions and in BD patients with folliculitis-like lesions when compared to controls (P < 0.05, respectively). Moreover, the frequency of HLA-DRB114 was significantly increased in BD patients under 20 years of age at the onset of disease (P < 0.01), while the frequency of HLA-DRB115 was significantly decreased in them (P < 0.05), compared with controls.

CONCLUSION

The results suggested that HLA-DRB1 alleles might play an important role in the onset and clinical manifestations of BD.

摘要

背景

贝切特病（BD）已知与多种族人群中的人类白细胞抗原（HLA）-B*51 相关。然而，根据不同的国家和地区，HLA Ⅱ类基因与 BD 的关联已被描述为不同。

目的

本研究旨在探讨 HLA-DRB1 等位基因多态性与 BD 的相关性。

方法

采用 LABType SSO 方法对 40 例 BD 患者和 100 例健康对照者进行 HLA-DRB1 等位基因分型。

结果

BD 患者 HLA-DRB114 频率显著高于对照组（P < 0.05），而 HLA-DRB115 频率显著低于对照组（P < 0.05）。在临床表现方面，BD 患者生殖器溃疡的 HLA-DRB115 频率显著低于对照组（P < 0.05）；BD 患者结节红斑样皮损和滤泡炎样皮损的 HLA-DRB114 频率显著高于对照组（P < 0.05，分别）。此外，HLA-DRB114 频率在发病年龄<20 岁的 BD 患者中显著增加（P < 0.01），而 HLA-DRB115 频率显著降低（P < 0.05），与对照组相比。