González-Escribano M F, Rodríguez M R, Walter K, Sanchez-Roman J, García-Lozano J R, Núñez-Roldán A
Servicio de Inmunología, Hospital Universitario Virgen del Rocio, Sevilla, Spain.
Tissue Antigens. 1998 Jul;52(1):78-80. doi: 10.1111/j.1399-0039.1998.tb03027.x.
We have studied the distribution of the different HLA-B51* alleles among patients with Behçet's disease (BD) and ethnically matched healthy controls in a Spanish population. The serological B51 specificity was increased in BD patients (37.5% versus 15.5% in controls). Among the B51-associated alleles, the frequencies of B5101 (32%) and 5108 (5.5%) were increased in BD patients with respect to the control frequencies (13% and 1.2% respectively). The fact that different HLA-B51 subtypes are associated with BD could suggest that common motifs shared by HLA-B51-related alleles are involved in the susceptibility to BD or, in the light of recent studies, that a mutation causing the susceptibility to BD occurred in the B5101 haplotype, close to HLA-B gene, before the divergence of B5108 from the B5101 allele.
我们研究了西班牙人群中白塞病（BD）患者及种族匹配的健康对照者中不同HLA - B51等位基因的分布情况。BD患者中血清学B51特异性升高（37.5%，而对照组为15.5%）。在与B51相关的等位基因中，BD患者中B5101（32%）和5108（5.5%）的频率相对于对照频率（分别为13%和1.2%）有所增加。不同的HLA - B51亚型与BD相关这一事实可能表明，HLA - B51相关等位基因共有的共同基序参与了BD易感性，或者根据最近的研究，在B5108从B5101等位基因分化之前，靠近HLA - B基因的B*5101单倍型中发生了导致BD易感性的突变。
