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The U1 snRNA gene repeat from the sea urchin (Strongylocentrotus purpuratus): the 70 kilobase tandem repeat ends directly 3' to a U1 gene.

作者信息

Yu J C, Wendelburg B, Sakallah S, Marzluff W F

机构信息

Department of Chemistry, Florida State University, Tallahassee 32306.

出版信息

Nucleic Acids Res. 1991 Mar 11;19(5):1093-8. doi: 10.1093/nar/19.5.1093.

DOI:10.1093/nar/19.5.1093
PMID:2020546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC333786/
Abstract

Lambda phage clones containing multiple copies of the 1.1 kb tandemly repeated unit of the sea urchin (S. purpuratus) U1 RNA genes were isolated from a gene library. The 1.1 kb repeat unit encodes a single copy of the predominant U1 RNA expressed in oocytes and embryos prior to the blastula stage. The tandem repeat unit is about 80 kb in size and is probably present one time per haploid genome as judged by pulsed-field electrophoresis of sperm DNA digested with restriction enzymes which do not cut in the repeat unit. Two of the phage contained DNA flanking the repeat unit as well as several repeat units. The tandem repeat unit ends just 3' to the U1 coding region. There is only limited homology in the 5' flanking region with U1 snRNA genes from the sea urchin L. variegatus.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572b/333786/ca57cb130caa/nar00241-0119-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572b/333786/164517891190/nar00241-0117-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572b/333786/ca57cb130caa/nar00241-0119-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572b/333786/164517891190/nar00241-0117-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572b/333786/ca57cb130caa/nar00241-0119-a.jpg

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The U1 snRNA gene repeat from the sea urchin (Strongylocentrotus purpuratus): the 70 kilobase tandem repeat ends directly 3' to a U1 gene.
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A conserved region in the sea urchin U1 snRNA promoter interacts with a developmentally regulated factor.海胆U1小核RNA启动子中的一个保守区域与一种发育调控因子相互作用。

本文引用的文献

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How a simple animal gene works.一个简单的动物基因是如何运作的。
Harvey Lect. 1980;76:27-44.
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The organization and expression of histone gene families.组蛋白基因家族的组织与表达
Cell. 1981 Aug;25(2):301-13. doi: 10.1016/0092-8674(81)90048-9.
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Expression and organization of histone genes.组蛋白基因的表达与组织
Nucleic Acids Res. 1992 Jan 25;20(2):351-7. doi: 10.1093/nar/20.2.351.
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Characterization of two developmentally regulated sea urchin U2 small nuclear RNA promoters: a common required TATA sequence and independent proximal and distal elements.两种发育调控的海胆U2小核RNA启动子的特性：一个共同的必需TATA序列以及独立的近端和远端元件。
Mol Cell Biol. 1992 Feb;12(2):650-60. doi: 10.1128/mcb.12.2.650-660.1992.
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Two promoter elements are necessary and sufficient for expression of the sea urchin U1 snRNA gene.两个启动子元件对于海胆U1 snRNA基因的表达是必需且充分的。
Nucleic Acids Res. 1992 Jul 25;20(14):3743-51. doi: 10.1093/nar/20.14.3743.
6
Formation of the 3' end of sea urchin U1 small nuclear RNA occurs independently of the conserved 3' box and on transcripts initiated from a histone promoter.海胆U1小核RNA 3'末端的形成独立于保守的3'框，且发生在由组蛋白启动子起始的转录本上。
Mol Cell Biol. 1992 Sep;12(9):4132-41. doi: 10.1128/mcb.12.9.4132-4141.1992.
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Compilation of small RNA sequences.小RNA序列的汇编
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Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis.通过脉冲场梯度凝胶电泳分离酵母染色体大小的DNA。
Cell. 1984 May;37(1):67-75. doi: 10.1016/0092-8674(84)90301-5.
5
Three linked chicken U1 RNA genes have limited flanking DNA sequence homologies that reveal potential regulatory signals.三个相连的鸡U1 RNA基因具有有限的侧翼DNA序列同源性，这些同源性揭示了潜在的调控信号。
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6
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J Biol Chem. 1984 Jul 10;259(13):8345-52.
7
Xenopus laevis U1 snRNA genes: characterisation of transcriptionally active genes reveals major and minor repeated gene families.非洲爪蟾U1小核RNA基因：转录活性基因的特征揭示了主要和次要的重复基因家族。
EMBO J. 1984 May;3(5):1075-81. doi: 10.1002/j.1460-2075.1984.tb01931.x.
8
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9
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The two embryonic U1 small nuclear RNAs of Xenopus laevis are encoded by a major family of tandemly repeated genes.非洲爪蟾的两个胚胎U1小核RNA由一个串联重复基因的主要家族编码。
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