天然产物来源的抗癌药物。

Anticancer agents derived from natural products.

机构信息

Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Ministry of Education, No. 24, Tongjia Lane, Nanjing 210009, China.

出版信息

Mini Rev Med Chem. 2009 Nov 1;9(13):1547-55. doi: 10.2174/138955709790361520.

DOI:10.2174/138955709790361520

PMID:20205636

Abstract

Advances in the prevention and treatment of cancer require the continued development of novel and improved chemopreventive and chemotherapeutic agents. Throughout history, natural products have afforded a rich source of anticancer agents with diverse chemical structures and bioactivities. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. In this review, we will present the anticancer activities, mechanism of action, structure and activity relationships of six important anticancer agents from natural products, that is, taxol, betulinic acid, camptothecin, resveratrol, podophyllotoxin and curcumin.

摘要

癌症的防治需要不断开发新的、改进的化学预防和化疗药物。纵观历史，天然产物为具有不同化学结构和生物活性的抗癌药物提供了丰富的来源。近年来，在结构阐明、有机合成和生物测定方面的技术和方法学进展，导致了各种新型抗癌药物的分离和临床评价。在这篇综述中，我们将介绍六种重要天然产物来源的抗癌药物，即紫杉醇、白桦脂酸、喜树碱、白藜芦醇、鬼臼毒素和姜黄素的抗癌活性、作用机制、结构与活性关系。