用于L-鸟氨酸有效正交保护以及5'-O-新戊酰基核苷氨基酰化的两条途径，描述了在核糖体模拟反应的模型底物过程中成功模拟的一般重要作用。

The two pathways for effective orthogonal protection of L-ornithine, for amino acylation of 5'-O-pivaloyl nucleosides, describe the general and important role for the successful imitation, during the model substrates for the ribosomal mimic reaction.

作者信息

Bayryamov Stanislav G, Vassilev Nikolay G, Petkov Dimiter D

机构信息

Laboratory of Biocatalysis, Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria.

出版信息

Protein Pept Lett. 2010 Jul;17(7):889-98. doi: 10.2174/092986610791306625.

DOI:10.2174/092986610791306625

PMID:20205650

Abstract

Bz(NO(2))-Orn(Boc)-OCH(2)CN was synthesized as an amino acid component with effective and successful orthogonal protection for amino acylation of 5'-O-Pivaloyl nucleosides and preparation of substrates for model ribosome reactions. The synthesis was carried out using suitable combinations of the methods of peptide synthesis and modification of amino acids.

摘要

Bz(NO(2))-Orn(Boc)-OCH(2)CN被合成为一种氨基酸组分，用于5'-O-新戊酰基核苷的氨酰化反应以及模型核糖体反应底物的制备，具有有效且成功的正交保护作用。该合成是通过肽合成方法和氨基酸修饰方法的适当组合来进行的。