Scrutinio Domenico
Division of Cardiology and Cardiac Rehabilitation, S. Maugeri Foundation, IRCCS. Institute of Cassano Murge. Bari. Italy.
Rev Recent Clin Trials. 2010 Jan;5(1):1-13. doi: 10.2174/157488710790820508.
There is overwhelming evidence that smoking cessation, regular physical activity, and combined dietary changes are beneficial in patients with coronary heart disease. Effect size estimates for these lifestyle goals vary between 20% and 35% of mortality rate reductions. Despite the evidence, achieving healthy lifestyles remains the most difficult problem in secondary prevention. In this paper, I review the effects of lifestyle changes on the clinical outcome of patients with coronary heart disease and the underlying mechanisms of benefit, as well as two recently published, controlled, clinical trials addressing the issue of achieving therapeutic lifestyle changes in coronary heart disease patients.
有压倒性的证据表明，戒烟、定期体育锻炼以及综合饮食改变对冠心病患者有益。这些生活方式目标的效应量估计为死亡率降低20%至35%。尽管有这些证据，但实现健康的生活方式仍然是二级预防中最困难的问题。在本文中，我回顾了生活方式改变对冠心病患者临床结局的影响及其获益的潜在机制，以及最近发表的两项针对冠心病患者实现治疗性生活方式改变问题的对照临床试验。
