Smolarz Joseph R, Hanna Ehab Y, Williams Michelle D, Kupferman Michael E
Department of Otorhinolaryngology, Head and Neck Surgery/Otolaryngology, The University of Texas Health Science Center at Houston, 6431 Fannin, Suite MSB 5.036, Houston, TX 77030, USA.
Head Neck Oncol. 2010 Jan 19;2:2. doi: 10.1186/1758-3284-2-2.
Less than 80 reported cases of paragangliomas of the larynx are reported in the literature. A role for external beam radiation in this disease has not yet been explored. We present four cases of laryngeal paragangliomas treated at a large tertiary-care cancer center over a 35-year period.
124 cases of head and neck paragangliomas treated at a single institution from 1970 to 2005 were retrospectively studied. Patients with laryngeal paragangliomas were identified, and a comprehensive clinico-pathological review was undertaken.
We identified 4 patients with tumors arising in the larynx at the following subsites: supraglottis (2), glottis (1), and subglottis (1). Three patients were treated with surgery and one with definitive radiation alone.
Laryngeal paragangliomas are rare tumors and are adequately treated with surgical resection. We also present one patient who was treated with radiation and had disease stabilization. Accurate histological classification is critical, and the role of genetic testing is emerging.
文献报道的喉副神经节瘤病例不足80例。尚未探讨外照射放疗在该疾病中的作用。我们介绍了在一家大型三级癌症中心35年间治疗的4例喉副神经节瘤病例。
回顾性研究了1970年至2005年在单一机构治疗的124例头颈部副神经节瘤患者。确定喉副神经节瘤患者，并进行全面的临床病理检查。
我们确定了4例肿瘤发生在喉部以下亚部位的患者：声门上区（2例）、声门区（1例）和声门下区（1例）。3例患者接受了手术治疗，1例仅接受了根治性放疗。
喉副神经节瘤是罕见肿瘤，手术切除可有效治疗。我们还介绍了1例接受放疗后病情稳定的患者。准确的组织学分类至关重要，基因检测的作用也日益显现。
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