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CD40单克隆抗体佐剂可诱导快速的抗体反应，这可能对暴露后预防有益。

CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis.

作者信息

Bhagawati-Prasad Vijay Ns, De Leenheer Evy, Keefe Nadine P, Ryan Lorna A, Carlring Jennifer, Heath Andrew W

机构信息

Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.

Adjuvantix Ltd, c/o Fusion plc, Sheffield Bioincubator, Leavygreave Rd, Sheffield, UK.

出版信息

J Immune Based Ther Vaccines. 2010 Feb 4;8:1. doi: 10.1186/1476-8518-8-1.

DOI:10.1186/1476-8518-8-1
PMID:20205811
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2824643/
Abstract

Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A.

摘要

主动免疫接种作为暴露后预防措施可能有效，但相对于病原体的潜伏期，诱导的免疫反应速度至关重要。我们在此表明，与抗原偶联的CD40单克隆抗体比目前使用的免疫佐剂明矾和单磷酰脂质A诱导出更快的特异性抗体反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05be/2824643/e77e161eedaf/1476-8518-8-1-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05be/2824643/e77e161eedaf/1476-8518-8-1-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05be/2824643/e77e161eedaf/1476-8518-8-1-1.jpg

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Immunology of TLR-independent vaccine adjuvants.
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Vaccine adjuvants: the dream becomes real.疫苗佐剂：梦想照进现实。
Hum Vaccin. 2008 Sep-Oct;4(5):347-9. doi: 10.4161/hv.4.5.6438. Epub 2008 Sep 16.
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