CD40单克隆抗体佐剂可诱导快速的抗体反应，这可能对暴露后预防有益。
CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis.
作者信息
Bhagawati-Prasad Vijay Ns, De Leenheer Evy, Keefe Nadine P, Ryan Lorna A, Carlring Jennifer, Heath Andrew W
机构信息
Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
Adjuvantix Ltd, c/o Fusion plc, Sheffield Bioincubator, Leavygreave Rd, Sheffield, UK.
出版信息
J Immune Based Ther Vaccines. 2010 Feb 4;8:1. doi: 10.1186/1476-8518-8-1.
Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A.
主动免疫接种作为暴露后预防措施可能有效，但相对于病原体的潜伏期，诱导的免疫反应速度至关重要。我们在此表明，与抗原偶联的CD40单克隆抗体比目前使用的免疫佐剂明矾和单磷酰脂质A诱导出更快的特异性抗体反应。
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