Pancratistatin 可诱导临床白血病样本凋亡，而对非癌细胞外周血单个核细胞的影响较小。
Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells.
机构信息
Department of Chemistry & Biochemistry, University of Windsor, Windsor, ON Canada.
出版信息
Cancer Cell Int. 2010 Mar 6;10:6. doi: 10.1186/1475-2867-10-6.
BACKGROUND
Pancratistatin, a natural compound extracted from Hymenocallis littoralis, can selectively induce apoptosis in several cancer cell lines. In this ex vivo study, we evaluated the effect of pancratistatin on peripheral blood mononuclear cells obtained from 15 leukemia patients prior to clinical intervention of newly diagnosed patients, as well as others of different ages in relapse and at various disease progression states.
RESULTS
Mononuclear cells from healthy volunteers and leukemia patients were exposed to 1 microM pancratistatin for up to 48 h. Irrespective of leukemia type, pancratistatin induced apoptosis in the leukemic samples, with minimal effects on non-cancerous peripheral blood mononuclear control cells.
CONCLUSION
Our results show that pancratistatin is an effective and selective anti-cancer agent with potential for advancement to clinical trials.
背景
从海滨蝎尾蕉中提取的天然化合物 Pancratistatin 可以选择性地诱导几种癌细胞系凋亡。在这项体外研究中，我们评估了 Pancratistatin 对新诊断患者临床干预前的 15 例白血病患者外周血单个核细胞以及其他不同年龄、不同复发和不同疾病进展状态患者的影响。
结果
将来自健康志愿者和白血病患者的单核细胞暴露于 1μM Pancratistatin 长达 48 小时。无论白血病类型如何，Pancratistatin 均可诱导白血病样本凋亡，对非癌性外周血单个核对照细胞的影响很小。
结论
我们的研究结果表明，Pancratistatin 是一种有效且选择性的抗癌药物，具有推进临床试验的潜力。
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