Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, RS, Brazil.
BMC Infect Dis. 2010 Mar 7;10:54. doi: 10.1186/1471-2334-10-54.
To describe the characteristics of patients with tuberculosis (TB) requiring intensive care and to identify the factors that predicts in-hospital mortality in a city of a developing country with intermediate-to-high TB endemicity.
We conducted a retrospective, cohort study, between November 2005 and November 2007. The patients with TB requiring intensive care were included. Predictors of mortality were assessed. The primary outcome was the in-hospital mortality.
During the study period, 67 patients with TB required intensive care. Of them, 62 (92.5%) had acute respiratory failure and required mechanical ventilation. Forty-four (65.7%) patients died. Coinfection with human immunodeficiency virus was present in 46 (68.7%) patients. Early intensive care unit admission and ventilator-associated pneumonia were independently associated with the in-hospital mortality.
In this study we found a high mortality rate in TB patients requiring intensive care, especially in those with an early ICU admission.
描述发展中国家中等至高度结核病流行地区需要重症监护的结核病（TB）患者的特征，并确定预测住院死亡率的因素。
我们进行了一项回顾性队列研究，时间为 2005 年 11 月至 2007 年 11 月。纳入需要重症监护的结核病患者。评估了死亡率的预测因素。主要结局是住院死亡率。
在研究期间，67 例结核病患者需要重症监护。其中，62 例（92.5%）有急性呼吸衰竭，需要机械通气。44 例（65.7%）患者死亡。46 例（68.7%）患者合并人类免疫缺陷病毒感染。早期重症监护病房入住和呼吸机相关性肺炎与住院死亡率独立相关。
在这项研究中，我们发现需要重症监护的结核病患者死亡率较高，尤其是那些早期入住重症监护病房的患者。
