Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Braz J Med Biol Res. 2023 Jan 27;56:e12236. doi: 10.1590/1414-431X2023e12236. eCollection 2023.
Determining outcomes and predictors of mortality following discharge from tuberculosis (TB) hospitalization is crucial to establish health policies. The objective of this study was to analyze outcomes and, secondarily, predictors of mortality following discharge from TB hospitalization. This was a prospective cohort study of patients diagnosed with TB (all forms) discharged from the hospital who began treatment during hospitalization. Out of 169 subjects included, 38 died during the 13-months of follow-up, within a median of 3 months (95%CI: 1.49-4.51). In the multivariate analysis, the variables independently associated with death were age (HR=1.04, 95%CI: 1.01-1.06, P=0.001), presence of sputum production (HR=2.18, 95%CI: 1.09-4.34, P=0.027), and Charlson Comorbidity Index (HR=1.19, 95%CI: 1.04-1.36, P=0.015). In conclusion, post-discharge mortality in subjects hospitalized for TB was 22.5%, with mean survival of 4.6 months. The mortality was higher in older subjects, in those who reported sputum production, and in those with a high comorbidity index.
确定结核病（TB）住院患者出院后的结局和死亡预测因素对于制定卫生政策至关重要。本研究的目的是分析 TB 住院患者出院后的结局，并分析其次的死亡预测因素。这是一项对在住院期间开始治疗的所有类型 TB 出院患者进行的前瞻性队列研究。在 169 名纳入患者中，有 38 名在 13 个月的随访期间内死亡，中位数为 3 个月（95%CI：1.49-4.51）。在多变量分析中，与死亡独立相关的变量为年龄（HR=1.04，95%CI：1.01-1.06，P=0.001）、有痰生成（HR=2.18，95%CI：1.09-4.34，P=0.027）和 Charlson 合并症指数（HR=1.19，95%CI：1.04-1.36，P=0.015）。总之，TB 住院患者出院后的死亡率为 22.5%，平均生存时间为 4.6 个月。年龄较大、有痰生成和合并症指数较高的患者死亡率更高。
