Microbial Ecophysiology and Nutrition Group, Institute of Agrochemistry and Food Technology (IATA), Spanish National Research Council (CSIC), Valencia, Spain.
Br J Nutr. 2010 Jul;104(1):83-92. doi: 10.1017/S0007114510000176. Epub 2010 Mar 8.
Obesity is associated with complications during pregnancy and increased health risks in the newborn. The objective of the present study was to establish possible relationships between gut microbiota, body weight, weight gain and biochemical parameters in pregnant women. Fifty pregnant women were classified according to their BMI in normal-weight (n 34) and overweight (n 16) groups. Gut microbiota composition was analysed by quantitative real-time PCR in faeces and biochemical parameters in plasma at 24 weeks of pregnancy. Reduced numbers of Bifidobacterium and Bacteroides and increased numbers of Staphylococcus, Enterobacteriaceae and Escherichia coli were detected in overweight compared with normal-weight pregnant women. E. coli numbers were higher in women with excessive weight gain than in women with normal weight gain during pregnancy, while Bifidobacterium and Akkermansia muciniphila showed an opposite trend. In the whole population, increased total bacteria and Staphylococcus numbers were related to increased plasma cholesterol levels. Increased Bacteroides numbers were related to increased HDL-cholesterol and folic acid levels, and reduced TAG levels. Increased Bifidobacterium numbers were related to increased folic acid levels. Increased Enterobacteriaceae and E. coli numbers were related to increased ferritin and reduced transferrin, while Bifidobacterium levels showed the opposite trend. Therefore, gut microbiota composition is related to body weight, weight gain and metabolic biomarkers during pregnancy, which might be of relevance to the management of the health of women and infants.
肥胖与孕妇孕期并发症和新生儿健康风险增加有关。本研究旨在确定孕妇肠道微生物群、体重、体重增加和生化参数之间的可能关系。将 50 名孕妇根据 BMI 分为正常体重组（n=34）和超重组（n=16）。在妊娠 24 周时，通过定量实时 PCR 分析粪便中的肠道微生物群组成和血浆中的生化参数。与正常体重孕妇相比，超重孕妇的双歧杆菌和拟杆菌数量减少，葡萄球菌、肠杆菌科和大肠杆菌数量增加。与体重正常增加的孕妇相比，体重过度增加的孕妇的大肠杆菌数量更高，而双歧杆菌和阿克曼氏菌的数量则呈现相反的趋势。在整个人群中，总细菌和葡萄球菌数量的增加与血浆胆固醇水平的升高有关。拟杆菌数量的增加与高密度脂蛋白胆固醇和叶酸水平的升高以及 TAG 水平的降低有关。双歧杆菌数量的增加与叶酸水平的升高有关。肠杆菌科和大肠杆菌数量的增加与铁蛋白的升高和转铁蛋白的降低有关，而双歧杆菌水平则呈现相反的趋势。因此，肠道微生物群组成与孕妇体重、体重增加和代谢生物标志物有关，这可能与妇女和婴儿健康的管理有关。
