Department of Pediatrics, Division of Genetic and Metabolic Disorders, Wayne State University School of Medicine, Detroit, Michigan, USA.
Obesity (Silver Spring). 2011 Jul;19(7):1476-81. doi: 10.1038/oby.2011.43. Epub 2011 Mar 10.
Maternal obesity may be associated with metabolic factors that affect the intrauterine environment, fetal growth, and the offspring's long-term risk for chronic disease. Among these factors, maternal serum lipids play a particularly important role. Our objective was to estimate the influence of variation in maternal serum lipid levels on variation in infant birth weight (BW) in overweight/obese and normal weight women. In a prospective cohort of 143 gravidas, we measured maternal serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) at 6-10, 10-14, 16-20, 22-26, and 32-36 weeks gestation. Effects of maternal serum lipid levels on infant BW adjusted for gestational age at delivery (aBW) were analyzed using linear regression models. In analyses stratified by maternal prepregnancy BMI categorized as normal (≤25.0 kg/m(2)) and overweight/obese (>25.0 kg/m(2)), we found a significant (P < 0.05) inverse association between aBW and HDL-C at all time points starting at 10 weeks gestation in overweight/obese women. No significant effect was found in normal weight women. In contrast, increased maternal serum TG was significantly associated with increased aBW only for normal weight women at 10-14 and 22-26 weeks gestation. Variation in aBW is not associated with variation in maternal serum TC or LDL-C for either stratum at any time point. We postulate that such differences may be involved in the "physiological programming" that influences later risk of chronic disease in the infants of overweight/obese mothers.
母体肥胖可能与代谢因素有关，这些因素会影响子宫内环境、胎儿生长和后代患慢性病的长期风险。在这些因素中，母体血清脂质起着特别重要的作用。我们的目的是估计母体血清脂质水平的变化对超重/肥胖和正常体重女性的婴儿出生体重（BW）变化的影响。在一项前瞻性队列研究中，我们在 143 名孕妇中测量了总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）在妊娠 6-10、10-14、16-20、22-26 和 32-36 周时的血清水平。使用线性回归模型分析了校正分娩时胎龄（aBW）的母体血清脂质水平对婴儿 BW 的影响。在按母体孕前 BMI 分层的分析中，将 BMI 分为正常（≤25.0kg/m2）和超重/肥胖（>25.0kg/m2），我们发现，从妊娠 10 周开始，超重/肥胖女性在所有时间点上，aBW 与 HDL-C 呈显著负相关（P<0.05）。在正常体重女性中未发现显著影响。相反，只有在妊娠 10-14 和 22-26 周时，正常体重女性的母体血清 TG 增加与 aBW 显著相关。在任何时间点，对于任何一个 BMI 组，BW 的变化都与母体血清 TC 或 LDL-C 的变化无关。我们推测，这些差异可能与影响超重/肥胖母亲后代慢性病后期风险的“生理编程”有关。
