Mgat1 依赖性 N-聚糖对于脊椎动物和无脊椎后生动物的正常发育都是必不可少的。
Mgat1-dependent N-glycans are essential for the normal development of both vertebrate and invertebrate metazoans.
机构信息
Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada.
出版信息
Semin Cell Dev Biol. 2010 Aug;21(6):609-15. doi: 10.1016/j.semcdb.2010.02.010. Epub 2010 Mar 3.
PMID:20206280
Abstract
UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I (GnTI, encoded by Mgat1) first appeared in evolution at about the same time as metazoa suggesting that GnTI-dependent glycans are essential for the development of multicellular organisms. This review describes the effects of mutations in the Mgat1 gene on the development of Caenorhabditis elegans, Drosophila melanogaster and mice.
摘要
UDP-GlcNAc:alpha3-D-甘露糖基-β1,2-N-乙酰氨基葡萄糖基转移酶 I (GnTI，由 Mgat1 编码) 在进化中大约与后生动物同时出现，表明 GnTI 依赖性聚糖对于多细胞生物的发育是必不可少的。本综述描述了 Mgat1 基因突变对秀丽隐杆线虫、黑腹果蝇和小鼠发育的影响。
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