基于人群的病例对照研究中男性型秃发与前列腺癌风险。
Male pattern baldness and prostate cancer risk in a population-based case-control study.
机构信息
Department of Urology, University of Washington School of Medicine, Seattle, WA, United States.
出版信息
Cancer Epidemiol. 2010 Apr;34(2):131-5. doi: 10.1016/j.canep.2010.02.003. Epub 2010 Mar 4.
PURPOSE
Male pattern baldness (MPB) and prostate cancer (PCa) share commonality as prevalent, heritable and androgen-related conditions. Studies exploring the relationship between the two conditions have been inconclusive. Using a population-based, case-control study of PCa, we explore the relationship between early-onset MPB and PCa risk.
METHODS
Cases were men aged 35-74 diagnosed with PCa between 2002 and 2005 in King County, Washington. Controls were frequency matched by age and identified by random digit dialing. Hair pattern at age 30 and at 1 year prior to diagnosis (cases) or reference date (controls) was determined using showcards. PCa risk associated with balding was assessed with logistic regression.
RESULTS
Data from 999 cases of PCa and 942 controls were analyzed. Hair loss at age 30 was more common in controls (25.2%) than cases (19.8%, p=0.005), and those with hair loss at age 30 had a 29% relative risk reduction for PCa (OR 0.71, 95% CI 0.56-0.91). No risk reduction was seen for men only reporting hair loss at referent age (OR 0.90, 95% CI 0.73-1.12). In men aged >60 at referent date, the risk reduction was greater for men with hair loss at age 30 from both the top of head and forehead (OR 0.55, 95% CI 0.33-0.93).
CONCLUSION
Early-onset MPB was associated with a reduced relative risk of PCa in this population-based study. Further research into a possible mechanistic link between these prevalent and androgen-related conditions is warranted.
目的
男性型秃发（MPB）和前列腺癌（PCa）具有共同的特征，即普遍存在、遗传性和雄激素相关。探索这两种疾病之间关系的研究尚无定论。本研究使用基于人群的 PCa 病例对照研究，探索早发性 MPB 与 PCa 风险之间的关系。
方法
病例为 2002 年至 2005 年期间在华盛顿金县诊断为 PCa 的 35-74 岁男性。对照通过年龄频数匹配，并通过随机数字拨号确定。通过展示卡确定 30 岁时和诊断（病例）或参考日期（对照）前 1 年的发式。使用逻辑回归评估秃发与 PCa 风险的相关性。
结果
分析了 999 例 PCa 病例和 942 例对照的数据。对照组（25.2%）中 30 岁时脱发的比例高于病例组（19.8%，p=0.005），30 岁时脱发的患者 PCa 的相对风险降低了 29%（OR 0.71，95%CI 0.56-0.91）。仅在参考年龄报告脱发的男性未观察到风险降低（OR 0.90，95%CI 0.73-1.12）。在参考日期年龄 >60 岁的男性中，30 岁时从头顶和前额脱发的男性风险降低更大（OR 0.55，95%CI 0.33-0.93）。
结论
在这项基于人群的研究中，早发性 MPB 与 PCa 的相对风险降低相关。需要进一步研究这两种普遍存在且与雄激素相关的疾病之间可能存在的机制联系。
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