趋化因子在调节抗利什曼病免疫中的作用。
Role of chemokines in regulation of immunity against leishmaniasis.
机构信息
Department of Pathology, The Ohio State University Medical Center, 1645 Neil Avenue, Columbus, OH 43210, USA.
出版信息
Exp Parasitol. 2010 Nov;126(3):389-96. doi: 10.1016/j.exppara.2010.02.010. Epub 2010 Mar 3.
Abstract
Successful immunity to Leishmania depends on recruitment of appropriate immune effector cells to the site of infection and chemokines play a crucial role in the process. At the same time, Leishmania parasites possess the ability to modify the chemokine profiles of their host thereby facilitating establishment of progressive infection. Therapeutic and prophylactic strategies targeted at chemokines and their receptors provide a promising area for further research. This review highlights our current knowledge concerning the role of chemokines and their receptors in modulating leishmaniasis in both clinical settings and experimental disease models.
摘要
成功抵御利什曼原虫依赖于适当的免疫效应细胞向感染部位的募集，趋化因子在此过程中起着至关重要的作用。与此同时，利什曼原虫寄生虫具有修饰宿主趋化因子谱的能力，从而促进进行性感染的建立。针对趋化因子及其受体的治疗和预防策略为进一步研究提供了一个有前途的领域。本综述重点介绍了我们目前对趋化因子及其受体在调节临床和实验疾病模型中利什曼病方面的作用的了解。
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