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用于分析利什曼病免疫反应的动物模型。

Animal models for the analysis of immune responses to leishmaniasis.

作者信息

Sacks David L, Melby Peter C

机构信息

National Institute of Allergy & Infectious Diseases, Bethesda, Maryland.

University of Texas Medical Branch (UTMB), Galveston, Texas.

出版信息

Curr Protoc Immunol. 2015 Feb 2;108:19.2.1-19.2.24. doi: 10.1002/0471142735.im1902s108.

DOI:10.1002/0471142735.im1902s108
PMID:25640990
Abstract

This unit focuses on the murine model of cutaneous leishmaniasis and models of visceral leishmaniasis in mice and hamsters. Each basic protocol describes the methods used to inoculate parasites and to evaluate infections with regard to lesion progression and visceralization, and quantification of parasite load.

摘要

本单元重点介绍皮肤利什曼病的小鼠模型以及小鼠和仓鼠内脏利什曼病的模型。每个基本方案都描述了接种寄生虫的方法,以及根据病变进展、内脏化和寄生虫负荷定量来评估感染情况的方法。

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