Simpson K M, Dileepan K N, Stechschulte D J
Department of Internal Medicine, University of Kansas Medical Center, Kansas City 66103.
Proc Soc Exp Biol Med. 1991 May;197(1):44-8. doi: 10.3181/00379727-197-43222.
Peptides such as parathyroid hormone (PTH), somatostatin, and gastrin have been reported to stimulate mast cell mediator release. Preincubation of rat serosal mast cells with synthetic 1-34 bovine parathyroid hormone (1-34bPTH) significantly enhanced antigen-induced 5-hydroxytryptamine (5-HT) release. Enhancement of 5-HT release by 1-34bPTH was dose dependent between 5 and 2000 nM. In the absence of antigen, mean net 5-HT release was less than 1% when naive or passively sensitized mast cells were incubated with 1000 nM 1-34bPTH for time intervals up to 90 min. These findings indicate that 1-34bPTH, at relatively low concentration, potentiates antigen-induced 5-HT release from mast cells.
据报道，甲状旁腺激素（PTH）、生长抑素和胃泌素等肽类可刺激肥大细胞介质释放。用合成的1-34牛甲状旁腺激素（1-34bPTH）对大鼠浆膜肥大细胞进行预孵育，可显著增强抗原诱导的5-羟色胺（5-HT）释放。1-34bPTH对5-HT释放的增强作用在5至2000 nM之间呈剂量依赖性。在无抗原的情况下，当未致敏或被动致敏的肥大细胞与1000 nM 1-34bPTH孵育长达90分钟时，平均净5-HT释放量小于1%。这些发现表明，相对低浓度的1-34bPTH可增强肥大细胞对抗原诱导的5-HT释放。
