Govindarajan S, Cassidy W M, Valinluck B, Redeker A G
University of Southern California School of Medicine, Liver Unit, Rancho Los Amigos Medical Center, Downey.
Prog Clin Biol Res. 1991;364:207-10.
From this study, we can conclude that there is significant influence of HIV infection on the clinical course of chronic HDV as follows: In these patients, there is simultaneous replication of both HBV and HDV and the suppression of HBV by HDV is modified. There is decreased antibody response to HDV, however, the degree of liver injury is not altered. Although these patients tend to have "reactivation episodes" as frequently as the HIV negative group, no correlation of serum ALT to HDV-RNA could be found. The possibility of these episodes resulting from injury due to other viruses such as non-A, non-B cannot be excluded.
从这项研究中，我们可以得出结论，HIV感染对慢性丁型肝炎病毒（HDV）的临床病程有显著影响，具体如下：在这些患者中，乙肝病毒（HBV）和HDV同时复制，HDV对HBV的抑制作用发生改变。对HDV的抗体反应降低，然而，肝损伤程度未改变。尽管这些患者与HIV阴性组一样频繁出现“再激活发作”，但未发现血清谷丙转氨酶（ALT）与HDV核糖核酸（HDV-RNA）之间存在相关性。不能排除这些发作是由其他病毒（如非甲非乙型肝炎病毒）造成损伤所致的可能性。
